Mission
The mission of our lab is to dissect fundamental mechanisms of cell division with a focus on midbody (MB) and midbody remnant (MBR) which mediate functions essential for cell division, proliferation, pluripotency, and cell-cell communication.
Our curiosity-driven investigations are founded on the premise that mutations in midbody proteins disrupt essential cellular processes, and reveal pathways central to human physiology and disease, which we call 'midbody-opathies'. Specifically we focus on pathways involving midbody RNAs and proteins that are disrupted in genetically-defined cancer and neurodegenerative diseases.
Our curiosity-driven investigations are founded on the premise that mutations in midbody proteins disrupt essential cellular processes, and reveal pathways central to human physiology and disease, which we call 'midbody-opathies'. Specifically we focus on pathways involving midbody RNAs and proteins that are disrupted in genetically-defined cancer and neurodegenerative diseases.
Translation in the midbody matrix in HeLa cells (Park, 2023)
Our curiosity-driven investigations have made key discoveries
The midbody is an actively translating large extracellular vesicle with phase separated RNA assembled by KIF23 and ARC
Park, S., Dahn, RD, Kurt, E., Presle, A, VanDenHeuvel, K., Moravec, C., Jambhekar, A., Olukoga, O., Shepherd, J., Echard, A., Blower, MD., Skop, AR (2023). The midbody and midbody remnant are assembly sites for RNA and active translation. Developmental Cell, Aug 1:S1534-5807(23)00357-X. doi: 10.1016/j.devcel.2023.07.009. Online ahead of print. PMID: 37552987
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The meiotic midbody is important for developmental competence
Jung, GI, Londono-Vasquez, D., Park, S., Skop, AR., Balboula, A., Schindler, K. (2023). A meiotic midbody structure in mouse oocytes acts as a barrier for nascent translation to ensure developmental competence. Nature Communications, doi: https://doi.org/10.1101/2022.11.17.516899
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Midbody Remnants (MBRs) are large EVs generated during mitosis
Patel SA, Park S, Zhu D, Torr EE, Dureke AG, McIntyre A, Muzyka N, Severson J, Skop AR. Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle. Mol Biol Cell. 2024 Nov 13:mbcE23100384. doi: 10.1091/mbc.E23-10-0384. Epub ahead of print. PMID: 39535882.
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